Biosynthesis of Nicotinamide Mononucleotide: Current Metabolic Engineering Strategies, Challenges, and Prospects

Metabolic Engineering of Microalgal Based Biofuel Production: Prospects and Challenges

The current scenario in renewable energy is focused on development of alternate and sustainable energy sources, amongst which microalgae stands as one of the promising feedstock for biofuel production. It is well known that microalgae generate much larger amounts of biofuels in a shorter time than other sources based on plant seeds. However, the greatest challenge in a transition to algae-based...

Neonatal Medicine in Iran: Current Challenges and Prospects

Background: Pediatric medicine in Iran has been known as a specialty for more than 50 years; nevertheless, the neonatal-perinatal medicine is still in the first decades of its life. Regarding this, the present study was conducted toprovide an overall view of the current situation of the neonatal medicine, its challenges, and prospects in Iran.Methods: For the purpose of the study, a questionnai...

Challenges and prospects in PNP metabolic engineering and production Final

Current strategies and challenges in engineering a bioartificial kidney.

Renal replacement therapy was an early pioneer in both extra-corporeal organ replacement and whole organ transplantation. Today, the success of this pioneering work is directly demonstrated in the millions of patients worldwide successfully treated with dialysis and kidney transplantation. However, there remain significant shortcomings to current treatment modalities that limit clinical outcome...

Enzymatic synthesis of polymers containing nicotinamide mononucleotide.

Nicotinamide mononucleoside 5'-diphosphate in its reduced form is an excellent substrate for polynucleotide phosphorylase from Micrococcus luteus both in de novo polymerization reactions and in primer extension reactions. The oxidized form of the diphosphate is a much less efficient substrate; it can be used to extend primers but does not oligomerize in the absence of a primer. The cyanide addu...